Cortical thickness and mean diffusivity AD signatures at average age 56 predict 12‐year progression to mild cognitive impairment
نویسندگان
چکیده
منابع مشابه
The Risk of Incident Mild Cognitive Impairment and Progression to Dementia Considering Mild Cognitive Impairment Subtypes
BACKGROUND It remains unclear how demographic and clinical characteristics are related to the risk of incident mild cognitive impairment (MCI) by its subtypes. Moreover, the contribution of the subtypes of incident MCI to the progression to dementia remains puzzling. METHODS We used data collected by the National Alzheimer Coordinating Center. Our analysis sample included cognitively normal s...
متن کاملProgression and improvement after mild cognitive impairment
Objective We studied progression to dementia and improvement rates of mild cognitive impairment (MCI) to help clinicians decide whether or not to screen older people for MCI. Method Prospective cohort study in which 156 vulnerable patients with (n=24) and without (n=132) MCI are followed and reassessed after two years with MMSE and Camdex. Results Nine (38%) out of 24 patients initially diagnos...
متن کاملCortical thickness analysis to detect progressive mild cognitive impairment: a reference to Alzheimer's disease.
BACKGROUND/AIMS Mild cognitive impairment (MCI) is associated with an increased risk of Alzheimer's disease (AD). It would be advantageous to be able to distinguish the characteristics of those MCI patients with a high probability to progress to AD if one wishes to monitor the disease development and treatment. METHODS We assessed the baseline MRI and maximum of 7 years clinical follow-up dat...
متن کاملA Clinical Index to Predict Progression from Mild Cognitive Impairment to Dementia Due to Alzheimer's Disease
BACKGROUND Mild cognitive impairment is often a precursor to dementia due to Alzheimer's disease, but many patients with mild cognitive impairment never develop dementia. New diagnostic criteria may lead to more patients receiving a diagnosis of mild cognitive impairment. OBJECTIVE To develop a prediction index for the 3-year risk of progression from mild cognitive impairment to dementia rely...
متن کاملCombined rCBF and CSF biomarkers predict progression from mild cognitive impairment to Alzheimer's disease.
This study aimed to identify preclinical Alzheimer's disease (AD) in patients with mild cognitive impairment (MCI) using measurements of both regional cerebral blood flow (rCBF) and cerebrospinal fluid (CSF) biomarkers. Baseline rCBF assessments ((133)Xe method) were performed in 70 patients with MCI who were cognitively stable for 4-6 years, 69 patients with MCI who subsequently developed AD, ...
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ژورنال
عنوان ژورنال: Alzheimer's & Dementia
سال: 2020
ISSN: 1552-5260,1552-5279
DOI: 10.1002/alz.043486